Article #10 from the complete research library
Enhanced Immune Response by Chloride Ions
Antiviral innate immune response in non-myeloid cells is augmented by chloride ions via an increase in intracellular hypochlorous acid levels.
Authors: Sandeep Ramalingam, Baiyi Cai, Junsheng Wong, Matthew Twomey, Rui Chen
Journal: Scientific reports (2018)
Abstract in Hebrew:
Phagocytes destroy bacteria that are engulfed by producing hypochlorous acid (HOCl) from chloride ions (Cl-) and hydrogen peroxide within phagolysosomes, via the enzyme myeloperoxidase. HOCl, the active component in bleach, has antibacterial and antiviral properties. Since myeloperoxidase is essential for HOCl production, non-myeloid cells are considered incapable of producing HOCl. Here, we demonstrate that epithelial cells,
