Article #9 from the complete research library
Anti-Viral Defense Strategies
Temperature-dependent innate defense against the common cold virus limits viral replication at warm temperature in mouse airway cells.
Authors: Ellen F Foxman, James A Storer, Megan E Fitzgerald, Bethany R Wasik, Lin Hou
Journal: Proceedings of the National Academy of Sciences of the United States of America (2015)
Summary in Hebrew:
Most strains of human rhinovirus, the virus responsible for the common cold, replicate much more efficiently at the cooler temperatures found in the nasal cavity (33-35 degrees Celsius) than at core body temperature (37 degrees Celsius). To gain insight into the temperature-dependent growth mechanism, we compared the transcriptional response of primary airway epithelial cells from mice infected with rhinovirus at 33 degrees Celsius versus 37 degrees Celsius. M
